What the FDA labels say about taking them together
Fluoxetine and vortioxetine
Vortioxetine's FDA label of March 5, 2025 names fluoxetine in its drug interactions section; the fluoxetine label PlainMeds reads does not name vortioxetine.
Check it at the source: the fluoxetine FDA label on DailyMed (effective January 8, 2026, Dista Products Company); the vortioxetine FDA label on DailyMed (effective March 5, 2025, Takeda Pharmaceuticals America, Inc.).
What does the fluoxetine label say about vortioxetine?
Fluoxetine's label (effective January 8, 2026) does not name vortioxetine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Prozac), NDA018936 (Eli Lilly And Co), as published by Dista Products Company, effective January 8, 2026 (SPL set c88f33ed-6dfb-4c5e-bc01-d8e36dd97299), via openFDA; the full label on DailyMed
What does the vortioxetine label say about fluoxetine?
Vortioxetine label, drug interactionsExamples; bupropion, fluoxetine, paroxetine, quinidine
Source: FDA drug label (Trintellix), Takeda Pharmaceuticals America, Inc., effective March 5, 2025 (SPL set 1a5b68e2-14d0-419d-9ec6-1ca97145e838), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fluoxetine | Vortioxetine | |
|---|---|---|
| Labeled for | Depression, Anxiety, Bipolar disorder | Depression |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0519 per capsule 40 mg capsule | $17.20 per tablet 10 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once