Vilazodone and Itraconazole Interaction
Drug interaction information between Vilazodone and Itraconazole.
Vilazodone and Itraconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Vilazodone and Itraconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Itraconazole blocks the enzymes responsible for clearing vilazodone from your body. This leads to higher levels of the medication in your bloodstream.
FDA Label Information
Strong CYP3A4 Inhibitors (e.g., itraconazole, clarithromycin, voriconazole) The concomitant use of vilazodone hydrochloride tablets and strong CYP3A4 inhibitors increased the exposure of vilazodone compared to the use of vilazodone hydrochloride tablets alone [see Clinical Pharmacology (12.3)].
Vilazodone Also Interacts With
- Linezolid major
- Tranylcypromine major
- Warfarin moderate
- Carbamazepine minor
- Clarithromycin minor
Itraconazole Also Interacts With
- Isavuconazonium major
- Lurasidone major
- Pimozide major
- Methadone major
- Midazolam major
Frequently Asked Questions
What SPL severity band is on file for Vilazodone + Itraconazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Itraconazole has 116 labeled pairs on file vs Vilazodone's 10. In the minor band specifically: Vilazodone has 7 (also Carbamazepine, Clarithromycin, Rifampin, Voriconazole); Itraconazole has 77 (also Fluticasone, Meloxicam, Buspirone, Oxycodone).
What mechanism field is on file for Vilazodone and Itraconazole?
Itraconazole blocks the enzymes responsible for clearing vilazodone from your body. This leads to higher levels of the medication in your bloodstream.
Itraconazole carries more major-labeled pairs than Vilazodone
SPL source-record counts only. This page's band is minor · classes on file: Vilazodone (SSRI / 5-HT1A Partial Agonist); Itraconazole (Azole Antifungal).
Itraconazole has 19 major-labeled pairs vs Vilazodone's 2. This page itself is in the minor band, not the major band.
2 major · 1 moderate · 7 minor · 10 total
- Other minor peers for Vilazodone
- Carbamazepine
- Clarithromycin
- Rifampin
- Voriconazole
19 major · 20 moderate · 77 minor · 116 total
- Other minor peers for Itraconazole
- Fluticasone
- Meloxicam
- Buspirone
- Oxycodone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.