What the FDA labels say about taking them together
Risperidone and venlafaxine
Venlafaxine's FDA label (Venlafaxine Hydrochloride) of July 31, 2025 names risperidone in its drug interactions section; the risperidone labels PlainMeds reads (4) do not name venlafaxine. The venlafaxine label: “Risperidone - Venlafaxine administered under steady-state conditions at 150 mg/day slightly inhibited the CYP2D6-mediated metabolism of risperidone to its active metabolite, 9-hydroxyrisperidone, resulting in an …”
Check it at the source: the risperidone FDA label on DailyMed (effective May 28, 2026, Janssen Pharmaceuticals, Inc.); the venlafaxine FDA label on DailyMed (effective August 15, 2023, Viatris Specialty LLC).
What does the risperidone label say about venlafaxine?
Risperidone's label (effective May 28, 2026) and its 3 other brand-application labels do not name venlafaxine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (RISPERDAL), Janssen Pharmaceuticals, Inc., effective May 28, 2026 (SPL set 7e117c7e-02fc-4343-92a1-230061dfc5e0), via openFDA; the full label on DailyMed
What does the venlafaxine label say about risperidone?
Venlafaxine Hydrochloride label (Trigen Laboratories, LLC, July 31, 2025), drug interactionsRisperidone - Venlafaxine administered under steady-state conditions at 150 mg/day slightly inhibited the CYP2D6-mediated metabolism of risperidone (administered as a single 1 mg oral dose) to its active metabolite, 9-hydroxyrisperidone, resulting in an approximate 32% increase in risperidone AUC.
Source: FDA drug label (Venlafaxine Hydrochloride, NDA022104), Trigen Laboratories, LLC, effective July 31, 2025 (SPL set fdaed1c2-dd0a-4bf3-975a-86fe3e7f0c97), via openFDA
Source: FDA drug label (Effexor XR), NDA020699 (Upjohn), as published by Viatris Specialty LLC, effective August 15, 2023 (SPL set c848a5d8-ba94-4c84-80e3-0bf35fb8e32e), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Risperidone | Venlafaxine | |
|---|---|---|
| Labeled for | Bipolar disorder, Schizophrenia | Depression, Anxiety |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0368 per tablet 0.25 mg tablet | $0.0799 per capsule 75 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once