What the FDA labels say about taking them together
Rifampin and upadacitinib
Upadacitinib's FDA label of June 30, 2026 names rifampin in its drug interactions section; the rifampin label PlainMeds reads does not name upadacitinib. The upadacitinib label: “Upadacitinib exposure is decreased when it is co-administered with strong CYP3A4 inducers (such as rifampin), which may lead to reduced therapeutic effect.”
Check it at the source: the rifampin FDA label on DailyMed (effective February 11, 2026, Lupin Pharmaceuticals, Inc.); the upadacitinib FDA label on DailyMed (effective June 30, 2026, AbbVie Inc.).
What does the rifampin label say about upadacitinib?
Rifampin's label (effective February 11, 2026) does not name upadacitinib in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (rifampin), Lupin Pharmaceuticals, Inc., effective February 11, 2026 (SPL set b56004f0-f23d-47f6-80c7-39884fccbccc), via openFDA; the full label on DailyMed
What does the upadacitinib label say about rifampin?
Upadacitinib label, drug interactionsUpadacitinib exposure is decreased when it is co-administered with strong CYP3A4 inducers (such as rifampin), which may lead to reduced therapeutic effect [see Clinical Pharmacology ( 12.3 )].
Source: FDA drug label (Rinvoq), AbbVie Inc., effective June 30, 2026 (SPL set 2966aec7-2ef0-923c-d8ff-fe1a957bf095), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Rifampin | Upadacitinib | |
|---|---|---|
| Labeled for | n/a | Rheumatoid arthritis, Crohn's disease and ulcerative colitis |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.679 per capsule 300 mg capsule | $229.31 per tablet 15 mg tablet |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once