What the FDA labels say about taking them together
Ketoconazole and upadacitinib
Upadacitinib's FDA label of June 30, 2026 names ketoconazole in its drug interactions section; the ketoconazole label PlainMeds reads does not name upadacitinib. The upadacitinib label: “Upadacitinib exposure is increased when it is co-administered with a strong CYP3A4 inhibitor, which may increase the risk of adverse reactions.”
Check it at the source: the ketoconazole FDA label on DailyMed (effective January 28, 2026, E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC); the upadacitinib FDA label on DailyMed (effective June 30, 2026, AbbVie Inc.).
What does the ketoconazole label say about upadacitinib?
Ketoconazole's label (effective January 28, 2026) does not name upadacitinib in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (ketoconazole), E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC, effective January 28, 2026 (SPL set cad7c647-34a9-4e4e-83b3-8d78e58f588f), via openFDA; the full label on DailyMed
What does the upadacitinib label say about ketoconazole?
Upadacitinib label, drug interactionsUpadacitinib exposure is increased when it is co-administered with a strong CYP3A4 inhibitor (such as ketoconazole, clarithromycin, and grapefruit), which may increase the risk of adverse reactions [see Clinical Pharmacology ( 12.3 )].
Source: FDA drug label (Rinvoq), AbbVie Inc., effective June 30, 2026 (SPL set 2966aec7-2ef0-923c-d8ff-fe1a957bf095), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ketoconazole | Upadacitinib | |
|---|---|---|
| Labeled for | Fungal infections | Rheumatoid arthritis, Crohn's disease and ulcerative colitis |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.249 per gram 2% cream | $229.31 per tablet 15 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once