What the FDA labels say about taking them together
Clarithromycin and upadacitinib
Upadacitinib's FDA label of June 30, 2026 names clarithromycin in its drug interactions section; the clarithromycin label PlainMeds reads does not name upadacitinib. The upadacitinib label: “Upadacitinib exposure is increased when it is co-administered with a strong CYP3A4 inhibitor, which may increase the risk of adverse reactions.”
Check it at the source: the clarithromycin FDA label on DailyMed (effective April 9, 2026, Solaris Pharma Corporation); the upadacitinib FDA label on DailyMed (effective June 30, 2026, AbbVie Inc.).
What does the clarithromycin label say about upadacitinib?
Clarithromycin's label (effective April 9, 2026) does not name upadacitinib in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Clarithromycin), Solaris Pharma Corporation, effective April 9, 2026 (SPL set 4d42821d-ce7a-7d64-e063-6294a90a0875), via openFDA; the full label on DailyMed
What does the upadacitinib label say about clarithromycin?
Upadacitinib label, drug interactionsUpadacitinib exposure is increased when it is co-administered with a strong CYP3A4 inhibitor (such as ketoconazole, clarithromycin, and grapefruit), which may increase the risk of adverse reactions [see Clinical Pharmacology ( 12.3 )].
Source: FDA drug label (Rinvoq), AbbVie Inc., effective June 30, 2026 (SPL set 2966aec7-2ef0-923c-d8ff-fe1a957bf095), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Clarithromycin | Upadacitinib | |
|---|---|---|
| Labeled for | Bacterial infections, Acid reflux and ulcers | Rheumatoid arthritis, Crohn's disease and ulcerative colitis |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.466 per tablet 500 mg tablet | $229.31 per tablet 15 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once