Trimethoprim and Pioglitazone Interaction
Drug interaction information between Trimethoprim and Pioglitazone.
Trimethoprim and Pioglitazone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Trimethoprim and Pioglitazone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Trimethoprim slows down the liver's ability to break down pioglitazone. This can make the blood sugar-lowering effect of the medicine stronger than intended.
FDA Label Information
Sulfamethoxazole and trimethoprim potentiates the effect of oral hypoglycemics that are metabolized by CYP2C8 (e.g., pioglitazone, repaglinide, and rosiglitazone) or CYP2C9 (e.g., glipizide and glyburide) or eliminated renally via OCT2 (e.g., metformin).
Trimethoprim Also Interacts With
- Theophylline major
- Prenatal Multivitamin moderate
- Spironolactone moderate
- Spironolactone (Acne) moderate
- Metformin minor
Pioglitazone Also Interacts With
- Clarithromycin major
- Rifampin minor
- Gemfibrozil minor
- Abiraterone minor
- Dapagliflozin minor
Frequently Asked Questions
What SPL severity band is on file for Trimethoprim + Pioglitazone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Trimethoprim has 22 labeled pairs on file vs Pioglitazone's 10. In the minor band specifically: Trimethoprim has 18 (also Metformin, Glipizide, Warfarin, Methotrexate); Pioglitazone has 9 (also Rifampin, Gemfibrozil, Abiraterone, Dapagliflozin).
What mechanism field is on file for Trimethoprim and Pioglitazone?
Trimethoprim slows down the liver's ability to break down pioglitazone. This can make the blood sugar-lowering effect of the medicine stronger than intended.
Trimethoprim's labeled portfolio outnumbers Pioglitazone
SPL source-record counts only. This page's band is minor · classes on file: Trimethoprim (Dihydrofolate Reductase Inhibitor); Pioglitazone (Thiazolidinedione).
1 major · 3 moderate · 18 minor · 22 total
- Other minor peers for Trimethoprim
- Metformin
- Glipizide
- Warfarin
- Methotrexate
1 major · 0 moderate · 9 minor · 10 total
- Other minor peers for Pioglitazone
- Rifampin
- Gemfibrozil
- Abiraterone
- Dapagliflozin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.