What the FDA labels say about taking them together
Pioglitazone and trimethoprim
Neither FDA label names the other in its interaction, contraindication or warning sections. A label lists the interactions its studies and reports found; it is not a complete list, so ask a pharmacist before combining medicines. Labels read October 8, 2026.
Check it at the source: the pioglitazone FDA label on DailyMed (effective March 28, 2025, Takeda Pharmaceuticals America, Inc.); the trimethoprim FDA label on DailyMed (effective January 26, 2024, Dr. Reddy's Labratories Inc.).
What does the pioglitazone label say about trimethoprim?
Pioglitazone's label (effective March 28, 2025) does not name trimethoprim in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Actos), Takeda Pharmaceuticals America, Inc., effective March 28, 2025 (SPL set d2ddc491-88a9-4063-9150-443b4fa4330c), via openFDA; the full label on DailyMed
What does the trimethoprim label say about pioglitazone?
Trimethoprim's label (effective January 26, 2024) does not name pioglitazone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Trimethoprim), NDA018679 (Dr Reddys Labs Sa), as published by Dr. Reddy's Labratories Inc., effective January 26, 2024 (SPL set 73ccebc1-7412-2424-d62c-a5180ec52d81), via openFDA; the full label on DailyMed
A pharmacist or prescriber can say whether these two medicines suit one person together; PlainMeds does not grade interactions.
Both medicines on the record
| Pioglitazone | Trimethoprim | |
|---|---|---|
| Labeled for | Type 2 diabetes | Bacterial infections, Urinary tract infections |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0675 per tablet 15 mg tablet | $1.31 per tablet 100 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once