What the FDA labels say about taking them together
Indomethacin and trimethoprim
Neither FDA label names the other in its interaction, contraindication or warning sections. A label lists the interactions its studies and reports found; it is not a complete list, so ask a pharmacist before combining medicines. Labels read October 8, 2026.
Check it at the source: the indomethacin FDA label on DailyMed (effective December 19, 2025, Glenmark Pharmaceuticals Inc., USA); the trimethoprim FDA label on DailyMed (effective January 26, 2024, Dr. Reddy's Labratories Inc.).
What does the indomethacin label say about trimethoprim?
Indomethacin's label (effective December 19, 2025) and its 3 other brand-application labels do not name trimethoprim in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Indomethacin), Glenmark Pharmaceuticals Inc., USA, effective December 19, 2025 (SPL set f7ed39e2-5431-4e47-935c-c7441d058f94), via openFDA; the full label on DailyMed
What does the trimethoprim label say about indomethacin?
Trimethoprim's label (effective January 26, 2024) does not name indomethacin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Trimethoprim), NDA018679 (Dr Reddys Labs Sa), as published by Dr. Reddy's Labratories Inc., effective January 26, 2024 (SPL set 73ccebc1-7412-2424-d62c-a5180ec52d81), via openFDA; the full label on DailyMed
A pharmacist or prescriber can say whether these two medicines suit one person together; PlainMeds does not grade interactions.
Both medicines on the record
| Indomethacin | Trimethoprim | |
|---|---|---|
| Labeled for | Rheumatoid arthritis, Osteoarthritis | Bacterial infections, Urinary tract infections |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.210 per capsule 75 mg capsule | $1.31 per tablet 100 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once