What the FDA labels say about taking them together
Itraconazole and trazodone
Trazodone's FDA label of January 22, 2026 names itraconazole in its drug interactions section; itraconazole's label does not name trazodone itself but warns about its class (serotonin reuptake inhibitors). The trazodone label: “The use of trazodone should be avoided in patients with known QT prolongation or in combination with other drugs that are inhibitors of CYP3A4, or known to prolong QT interval including Class 1A antiarrhythmics or Class …”
Check it at the source: the itraconazole FDA label on DailyMed (effective July 13, 2026, Janssen Pharmaceuticals, Inc.); the trazodone FDA label on DailyMed (effective January 22, 2026, Zydus Pharmaceuticals USA Inc.).
What does the itraconazole label say about trazodone?
Itraconazole's label does not name trazodone itself; it warns about its class (serotonin reuptake inhibitors):
Itraconazole label, drug interactionsSSRIs, Tricyclics and Related Antidepressants Venlafaxine Monitor for adverse reactions.
Source: FDA drug label (SPORANOX), Janssen Pharmaceuticals, Inc., effective July 13, 2026 (SPL set a4d555fa-787c-40fb-bb7d-b0d4f7318fd0), via openFDA; the full label on DailyMed
What does the trazodone label say about itraconazole?
Trazodone label, drug interactionsExamples; itraconazole, ketoconazole, clarithromycin, indinavir
Trazodone label, warnings and precautionsThe use of trazodone should be avoided in patients with known QT prolongation or in combination with other drugs that are inhibitors of CYP3A4 (e.g., itraconazole, clarithromycin, voriconazole), or known to prolong QT interval including Class 1A antiarrhythmics (e.g., quinidine, procainamide) or Class 3 antiarrhythmics (e.g., amiodarone, sotalol), certain antipsychotic medications (e.g., ziprasidone, chlorpromazine, thioridazine), and certain antibiotics (e.g., gatifloxacin).
Source: FDA drug label (Raldesy Tm, NDA218637), Validus Pharmaceuticals LLC, effective September 1, 2026 (SPL set 34708cc1-b0b2-4fd0-b9f3-7f008b457fc9), via openFDA
Source: FDA drug label (Trazodone Hydrochloride), Zydus Pharmaceuticals USA Inc., effective January 22, 2026 (SPL set 704aebf9-2fff-4ef3-8323-9ff0d7f0ffd9), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Itraconazole | Trazodone | |
|---|---|---|
| Labeled for | Fungal infections | Depression |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.910 per capsule 100 mg capsule | $0.0307 per tablet 50 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once