What the FDA labels say about taking them together
Pseudoephedrine and tranylcypromine
Tranylcypromine's FDA label of July 2, 2025 names pseudoephedrine in its boxed warning section; pseudoephedrine's label does not name tranylcypromine itself but warns about its class (MAO inhibitors). The tranylcypromine label: “… medicines that can raise blood pressure (sympathomimetic medicine), such as pseudoephedrine, phenylephrine and ephedrine.”
Check it at the source: the pseudoephedrine FDA label on DailyMed (effective October 30, 2025, L. Perrigo Company); the tranylcypromine FDA label on DailyMed (effective July 2, 2025, Advanz Pharma (US) Corp.).
What does the pseudoephedrine label say about tranylcypromine?
Pseudoephedrine's label does not name tranylcypromine itself; it warns about its class (MAO inhibitors):
Pseudoephedrine label, warningsWarnings Do not use if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson’s disease), or for 2 weeks after stopping the MAOI drug.
Pseudoephedrine label, warningsIf you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product.
Source: FDA drug label (Good Sense Suphedrine 12 Hour), L. Perrigo Company, effective October 30, 2025 (SPL set 1de8a7f6-e7bb-437d-8794-c4b9f43b89c9), via openFDA; the full label on DailyMed
What does the tranylcypromine label say about pseudoephedrine?
Tranylcypromine label, boxed warningSee, "What is the most important information I should know about PARNATE?” and “What are the possible side effects of PARNATE?” Do not take PARNATE if you: take certain medicines, including: antidepressants, such as: other monoamine oxidase inhibitors (MAOIs) selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs) tricyclic antidepressants other antidepressants, such as amoxapine, bupropion, maprotiline, nefazodone, trazodone, vilazodone, vortioxetine amphetamines and methylphenidates medicines that can raise blood pressure (sympathomimetic medicine), such as pseudoephedrine, phenylephrine and ephedrine.
Tranylcypromine label, contraindicationsOther monoamine oxidase inhibitors (MAOIs) Selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs) Tricyclic antidepressants Other antidepressants (e.g., amoxapine, bupropion, maprotiline, nefazodone, trazodone, vilazodone, vortioxetine) Amphetamines and methylphenidates and derivatives Sympathomimetic products (e.g., cold, hay fever or weight reducing products that contain vasoconstrictors such as pseudoephedrine, phenylephrine, and ephedrine; …
Tranylcypromine label, drug interactions… Triptans Contraindicated a SS * Some drugs in these groups may also be listed in Table 4 below. ** Sympathomimetic drugs include amphetamines as well as cold, hay fever or weight-reducing products that contain vasoconstrictors such as pseudoephedrine, phenylephrine, and ephedrine) a [See Contraindications (4.1)]; b [See Warnings and Precautions (5.2)]; c [See Warnings and Precautions (5.3)] d If not otherwise specified in this table, consider avoiding concomitant use (see also information on medication-free intervals, use agent at the lowest appropriate dosage, monitor for effects of the interaction, advise the patient to report potential effects). e [See Warnings and Precautions (5.5)]; …
Source: FDA drug label (PARNATE), Advanz Pharma (US) Corp., effective July 2, 2025 (SPL set b72d8187-dfcc-4ea0-b5e9-c0be95b69a27), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Pseudoephedrine | Tranylcypromine | |
|---|---|---|
| Labeled for | Cough and cold | Depression |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.281 per tablet 120 mg tablet | $0.591 per tablet 10 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once