What the FDA labels say about taking them together
Tranexamic acid and tretinoin
Tranexamic acid's FDA label (Tranexamic Acid) of January 12, 2026 names tretinoin in its drug interactions section; the tretinoin labels PlainMeds reads (4) do not name tranexamic acid. The tranexamic acid label: “Acid (Oral Tretinoin) Tranexamic acid USP tablets are not recommended in patients with acute promyelocytic leukemia taking all-trans retinoic acid for remission induction because of possible exacerbation of the …”
Check it at the source: the tranexamic acid FDA label on DailyMed (effective September 3, 2025, Pfizer Laboratories Div Pfizer Inc); the tretinoin FDA label on DailyMed (effective May 17, 2024, Bausch Health US, LLC).
What does the tranexamic acid label say about tretinoin?
Tranexamic Acid label (AvPAK, January 12, 2026), drug interactionsAcid (Oral Tretinoin) Tranexamic acid USP tablets are not recommended in patients with acute promyelocytic leukemia taking all-trans retinoic acid for remission induction because of possible exacerbation of the procoagulant effect of all-trans retinoic acid [see Warnings and Precautions (5.1) ].
Tranexamic Acid label (AvPAK, January 12, 2026), warnings and precautionsConcomitant use of tranexamic acid USP tablets with combined hormonal contraceptives, Factor IX complex concentrates, anti-inhibitor coagulant concentrates or all-trans retinoic acid (oral tretinoin) may increase the risk of thrombosis. ( 5.1 ) Visual or ocular adverse reactions may occur with tranexamic acid USP tablets.
Source: FDA drug label (Tranexamic Acid, NDA022430), AvPAK, effective January 12, 2026 (SPL set e8cdb0d6-9498-2902-e053-2995a90a9de4), via openFDA
Source: FDA drug label (Cyklokapron), Pfizer Laboratories Div Pfizer Inc, effective September 3, 2025 (SPL set 6e89a7d9-4da4-42aa-b7f8-c602c24eefe5), via openFDA; the full label on DailyMed
What does the tretinoin label say about tranexamic acid?
Tretinoin's label (effective May 17, 2024) and its 3 other brand-application labels do not name tranexamic acid in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Retin-A), Bausch Health US, LLC, effective May 17, 2024 (SPL set 9556d73d-c573-4e0a-9feb-764ce2d1107b), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Tranexamic acid | Tretinoin | |
|---|---|---|
| Labeled for | n/a | Acne |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.404 per mL 1,000 mg/10 mL | $0.506 per gram 0.025% cream |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once