Tramadol and Paroxetine Interaction
Drug interaction information between Tramadol and Paroxetine.
Tramadol and Paroxetine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Tramadol and Paroxetine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Paroxetine blocks the process your body uses to get rid of tramadol. This can lead to more medicine in your system than intended.
FDA Label Information
Examples Quinidine, fluoxetine, paroxetine and bupropion Inhibitors of CYP3A4 Clinical Impact: The concomitant use of tramadol hydrochloride extended-release tablets and CYP3A4 inhibitors can increase the plasma concentration of tramadol and may result in a greater amount of metabolism via CYP2D6 and greater levels of M1.
Tramadol Also Interacts With
- Safinamide major
- Carbamazepine moderate
- Rifampin moderate
- Phenytoin moderate
- Gabapentin minor
Paroxetine Also Interacts With
- Linezolid major
- Pimozide major
- Thioridazine major
- Phenelzine moderate
- Tranylcypromine moderate
Frequently Asked Questions
What SPL severity band is on file for Tramadol + Paroxetine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Paroxetine has 51 labeled pairs on file vs Tramadol's 38. In the minor band specifically: Tramadol has 34 (also Gabapentin, Bupropion, Fluoxetine, Cyclobenzaprine); Paroxetine has 44 (also Buspirone, Clopidogrel, Aspirin, Venlafaxine).
What mechanism field is on file for Tramadol and Paroxetine?
Paroxetine blocks the process your body uses to get rid of tramadol. This can lead to more medicine in your system than intended.
Paroxetine carries more major-labeled pairs than Tramadol
SPL source-record counts only. This page's band is minor · classes on file: Tramadol (Opioid Analgesic); Paroxetine (Selective Serotonin Reuptake Inhibitor (SSRI)).
Paroxetine has 3 major-labeled pairs vs Tramadol's 1. This page itself is in the minor band, not the major band.
1 major · 3 moderate · 34 minor · 38 total
- Other minor peers for Tramadol
- Gabapentin
- Bupropion
- Fluoxetine
- Cyclobenzaprine
3 major · 4 moderate · 44 minor · 51 total
- Other minor peers for Paroxetine
- Buspirone
- Clopidogrel
- Aspirin
- Venlafaxine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.