Tizanidine and Mexiletine Interaction
Drug interaction information between Tizanidine and Mexiletine.
Tizanidine and Mexiletine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Tizanidine and Mexiletine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Mexiletine reduces your body's ability to get rid of tizanidine, which can increase the risk of a reaction.
FDA Label Information
7.2 Moderate or Weak CYP1A2 Inhibitors Concomitant use of tizanidine with moderate or weak CYP1A2 inhibitors (e.g., zileuton, antiarrhythmics [amiodarone, mexiletine, propafenone, and verapamil], cimetidine, famotidine, oral contraceptives, acyclovir, and ticlopidine) should be avoided.
Tizanidine Also Interacts With
- Ciprofloxacin major
- Fluvoxamine major
- Famotidine moderate
- Acyclovir minor
- Verapamil minor
Mexiletine Also Interacts With
- Lidocaine Topical moderate
- Propranolol minor
- Digoxin minor
- Propafenone minor
- Theophylline minor
Frequently Asked Questions
What SPL severity band is on file for Tizanidine + Mexiletine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Tizanidine has 17 labeled pairs on file vs Mexiletine's 14. In the minor band specifically: Tizanidine has 14 (also Acyclovir, Verapamil, Amiodarone, Propafenone); Mexiletine has 13 (also Propranolol, Digoxin, Propafenone, Theophylline).
What mechanism field is on file for Tizanidine and Mexiletine?
Mexiletine reduces your body's ability to get rid of tizanidine, which can increase the risk of a reaction.
Tizanidine carries more major-labeled pairs than Mexiletine
SPL source-record counts only. This page's band is minor · classes on file: Tizanidine (Central Alpha-2 Agonist (Muscle Relaxant)); Mexiletine (Class IB Antiarrhythmic).
Tizanidine has 2 major-labeled pairs vs Mexiletine's 0. This page itself is in the minor band, not the major band.
2 major · 1 moderate · 14 minor · 17 total
- Other minor peers for Tizanidine
- Acyclovir
- Verapamil
- Amiodarone
- Propafenone
0 major · 1 moderate · 13 minor · 14 total
- Other minor peers for Mexiletine
- Propranolol
- Digoxin
- Propafenone
- Theophylline
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.