What the FDA labels say about taking them together
Sucralfate and theophylline
Sucralfate's FDA label of September 2, 2026 names theophylline in its drug interactions section, and theophylline's label names sucralfate too. The sucralfate label: “… ketoconazole, l-thyroxine, phenytoin, quinidine, ranitidine, tetracycline, and theophylline.”
Check it at the source: the sucralfate FDA label on DailyMed (effective September 2, 2026, Preferred Pharmaceuticals Inc.); the theophylline FDA label on DailyMed (effective March 10, 2026, Strides Pharma Science Limited).
What does the sucralfate label say about theophylline?
Sucralfate label, drug interactionsDrug Interactions Some studies have shown that simultaneous sucralfate administration in healthy volunteers reduced the extent of absorption (bioavailability) of single doses of the following: cimetidine, digoxin, fluoroquinolone antibiotics, ketoconazole, l-thyroxine, phenytoin, quinidine, ranitidine, tetracycline, and theophylline.
Source: FDA drug label (Sucralfate), NDA018333 (Abbvie), as published by Preferred Pharmaceuticals Inc., effective September 2, 2026 (SPL set 536b8c00-13ab-4397-a754-63a1c92bf883), via openFDA; the full label on DailyMed
What does the theophylline label say about sucralfate?
Theophylline label, drug interactionsisoflurane; sucralfate
Source: FDA drug label (Theophylline), Strides Pharma Science Limited, effective March 10, 2026 (SPL set b7a90ccf-9c32-40cc-9008-7e55b3da4dfd), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Sucralfate | Theophylline | |
|---|---|---|
| Labeled for | Acid reflux and ulcers | Asthma |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.173 per tablet 1 g tablet | $0.330 per tablet 300 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once