What the FDA labels say about taking them together
Ofloxacin and theophylline
Ofloxacin's FDA label (Ocuflox) of June 13, 2024 names theophylline in its drug interactions section, and theophylline's label names ofloxacin too. The ofloxacin label: “However, the systemic administration of some quinolones has been shown to elevate plasma concentrations of theophylline, interfere with the metabolism of caffeine, and enhance the effects of the oral anticoagulant …”
Check it at the source: the ofloxacin FDA label on DailyMed (effective July 18, 2024, Amneal Pharmaceuticals NY LLC); the theophylline FDA label on DailyMed (effective March 10, 2026, Strides Pharma Science Limited).
What does the ofloxacin label say about theophylline?
Ocuflox label (Allergan, Inc., June 13, 2024), drug interactionsHowever, the systemic administration of some quinolones has been shown to elevate plasma concentrations of theophylline, interfere with the metabolism of caffeine, and enhance the effects of the oral anticoagulant warfarin and its derivatives, and has been associated with transient elevations in serum creatinine in patients receiving cyclosporine concomitantly.
Source: FDA drug label (Ocuflox, NDA019921), Allergan, Inc., effective June 13, 2024 (SPL set 7aab4449-3dda-4e2c-8e40-b3244a548bf5), via openFDA
Source: FDA drug label (Ofloxacin), Amneal Pharmaceuticals NY LLC, effective July 18, 2024 (SPL set ba37e2a0-1bf7-41ca-bddd-35fcb77f87de), via openFDA; the full label on DailyMed
What does the theophylline label say about ofloxacin?
Theophylline label, drug interactionsco-trimoxazole (trimethoprim and sulfamethoxazole); ofloxacin
Source: FDA drug label (Theophylline), Strides Pharma Science Limited, effective March 10, 2026 (SPL set b7a90ccf-9c32-40cc-9008-7e55b3da4dfd), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ofloxacin | Theophylline | |
|---|---|---|
| Labeled for | Bacterial infections | Asthma |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $1.24 per mL 0.3% eye drops | $0.330 per tablet 300 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once