What the FDA labels say about taking them together
Disulfiram and theophylline
Theophylline's FDA label of March 10, 2026 names disulfiram in its drug interactions section; the disulfiram label PlainMeds reads does not name theophylline. The theophylline label: “Disulfiram Decreases theophylline clearance by inhibiting hydroxylation and demethylation.”
Check it at the source: the disulfiram FDA label on DailyMed (effective August 20, 2024, Sigmapharm Laboratories, LLC); the theophylline FDA label on DailyMed (effective March 10, 2026, Strides Pharma Science Limited).
What does the disulfiram label say about theophylline?
Disulfiram's label (effective August 20, 2024) does not name theophylline in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Disulfiram), Sigmapharm Laboratories, LLC, effective August 20, 2024 (SPL set 40f5497f-fe84-43b2-8ff4-32d59edf3917), via openFDA; the full label on DailyMed
What does the theophylline label say about disulfiram?
Theophylline label, drug interactionsDisulfiram Decreases theophylline clearance by inhibiting hydroxylation and demethylation.
Source: FDA drug label (Theophylline), Strides Pharma Science Limited, effective March 10, 2026 (SPL set b7a90ccf-9c32-40cc-9008-7e55b3da4dfd), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Disulfiram | Theophylline | |
|---|---|---|
| Labeled for | Alcohol use disorder | Asthma |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $1.82 per tablet 250 mg tablet | $0.330 per tablet 300 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once