What the FDA labels say about taking them together
Teriflunomide and zidovudine
Teriflunomide's FDA label of February 20, 2026 names zidovudine in its drug interactions section; the zidovudine labels PlainMeds reads (3) do not name teriflunomide. The teriflunomide label: “In patients taking AUBAGIO, exposure of drugs which are OAT3 substrates may be increased.”
Check it at the source: the teriflunomide FDA label on DailyMed (effective February 20, 2026, Genzyme Corporation); the zidovudine FDA label on DailyMed (effective February 10, 2025, Aurobindo Pharma Limited).
What does the teriflunomide label say about zidovudine?
Teriflunomide label, drug interactionsIn patients taking AUBAGIO, exposure of drugs which are OAT3 substrates (e.g., cefaclor, cimetidine, ciprofloxacin, penicillin G, ketoprofen, furosemide, methotrexate, zidovudine) may be increased.
Source: FDA drug label (Aubagio), NDA202992 (Sanofi Aventis Us), as published by Genzyme Corporation, effective February 20, 2026 (SPL set 4650d12c-b9c8-4525-b07f-a2d773eca155), via openFDA; the full label on DailyMed
What does the zidovudine label say about teriflunomide?
Zidovudine's label (effective February 10, 2025) and its 2 other brand-application labels do not name teriflunomide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Zidovudine), Aurobindo Pharma Limited, effective February 10, 2025 (SPL set 51abd2ce-6be1-412d-b806-5f24935ac5e3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Teriflunomide | Zidovudine | |
|---|---|---|
| Labeled for | Multiple sclerosis | HIV |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.233 per tablet 14 mg tablet | $0.464 per tablet 300 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once