Telmisartan and Aliskiren Interaction
Drug interaction information between Telmisartan and Aliskiren.
Telmisartan and Aliskiren have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Telmisartan and Aliskiren. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medicines work on the same system to lower blood pressure, which can cause serious stress on the kidneys and high potassium levels.
FDA Label Information
7 DRUG INTERACTIONS Aliskiren: Do not co-administer aliskiren with telmisartan in patients with diabetes. Avoid use of aliskiren with telmisartan in patients with renal impairment (GFR <60 mL/min). NSAIDs : Increased risk of renal impairment and loss of anti-hypertensive effect ( 7 ) Do not co-administer aliskiren with telmisartan in patients with diabetes ( 7 )
Telmisartan Also Interacts With
View all Telmisartan interactions →Aliskiren Also Interacts With
- Amlodipine/Benazepril major
- Amlodipine/Valsartan major
- Azilsartan major
- Benazepril major
- Candesartan major
Frequently Asked Questions
What SPL severity band is on file for Telmisartan + Aliskiren?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Aliskiren has 28 labeled pairs on file vs Telmisartan's 4. In the major band specifically: Telmisartan has 1; Aliskiren has 22 (also Amlodipine/Benazepril, Amlodipine/Valsartan, Azilsartan, Benazepril).
What mechanism field is on file for Telmisartan and Aliskiren?
Both of these medicines work on the same system to lower blood pressure, which can cause serious stress on the kidneys and high potassium levels.
Aliskiren carries more major-labeled pairs than Telmisartan
SPL source-record counts only. This page's band is major · classes on file: Telmisartan (Angiotensin II Receptor Blocker (ARB)); Aliskiren (Direct Renin Inhibitor).
Aliskiren has 22 major-labeled pairs vs Telmisartan's 1.
1 major · 1 moderate · 2 minor · 4 total
Telmisartan has no other major-band peer in this dataset besides Aliskiren.
22 major · 3 moderate · 3 minor · 28 total
- Other major peers for Aliskiren
- Amlodipine/Benazepril
- Amlodipine/Valsartan
- Azilsartan
- Benazepril
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.