What the FDA labels say about taking them together
Repaglinide and tecovirimat
Tecovirimat's FDA label of December 31, 2025 names repaglinide in its drug interactions section; the repaglinide label PlainMeds reads does not name tecovirimat. The tecovirimat label: “Monitor blood glucose and monitor for hypoglycemic symptoms in patients when TPOXX is co-administered with repaglinide.”
Check it at the source: the repaglinide FDA label on DailyMed (effective May 2, 2025, Chartwell RX, LLC); the tecovirimat FDA label on DailyMed (effective December 31, 2025, SIGA Technologies, Inc.).
What does the repaglinide label say about tecovirimat?
Repaglinide's label (effective May 2, 2025) does not name tecovirimat in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Repaglinide), Chartwell RX, LLC, effective May 2, 2025 (SPL set cb995e92-295e-4638-a064-978211f5afe1), via openFDA; the full label on DailyMed
What does the tecovirimat label say about repaglinide?
Tecovirimat label, drug interactionsConcomitant Drug Class/Drug Name: Repaglinide b; Effect on Concentration a: ↑ repaglinide; Clinical Effect/Recommendation: Monitor blood glucose and monitor for hypoglycemic symptoms in patients when TPOXX is co-administered with repaglinide [see Warnings and Precautions ()].
Tecovirimat label, warnings and precautionsWARNINGS AND PRECAUTIONS Hypoglycemia: Co-administration with repaglinide may cause hypoglycemia.
Source: FDA drug label (TPOXX), SIGA Technologies, Inc., effective December 31, 2025 (SPL set fce826ab-4d6a-4139-a2ee-a304a913a253), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Repaglinide | Tecovirimat | |
|---|---|---|
| Labeled for | Type 2 diabetes | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0987 per tablet 1 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once