What the FDA labels say about taking them together
Midazolam and tecovirimat
Tecovirimat's FDA label of December 31, 2025 names midazolam in its drug interactions section; the midazolam labels PlainMeds reads (4) do not name tecovirimat. The tecovirimat label: “Monitor for effectiveness of midazolam.”
Check it at the source: the midazolam FDA label on DailyMed (effective January 1, 2024, Fresenius Kabi USA, LLC); the tecovirimat FDA label on DailyMed (effective December 31, 2025, SIGA Technologies, Inc.).
What does the midazolam label say about tecovirimat?
Midazolam's label (effective January 1, 2024) and its 3 other brand-application labels do not name tecovirimat in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Midazolam), Fresenius Kabi USA, LLC, effective January 1, 2024 (SPL set 1cc9ba6e-fa1b-405e-9de8-720c567b2a73), via openFDA; the full label on DailyMed
What does the tecovirimat label say about midazolam?
Tecovirimat label, drug interactionsConcomitant Drug Class/Drug Name: Midazolam b; Effect on Concentration a: ↓ midazolam; Clinical Effect/Recommendation: Monitor for effectiveness of midazolam.
Source: FDA drug label (TPOXX), SIGA Technologies, Inc., effective December 31, 2025 (SPL set fce826ab-4d6a-4139-a2ee-a304a913a253), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Midazolam | Tecovirimat | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.233 per mL 2 mg/2 mL vial | n/a |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once