What the FDA labels say about taking them together
Rifampin and tadalafil
Tadalafil's FDA label of June 3, 2026 names rifampin in its drug interactions section; the rifampin label PlainMeds reads does not name tadalafil. The tadalafil label: “Potent Inducers of CYP3A For patients chronically taking potent inducers of CYP3A, such as rifampin, avoid use of TADLIQ.”
Check it at the source: the rifampin FDA label on DailyMed (effective February 11, 2026, Lupin Pharmaceuticals, Inc.); the tadalafil FDA label on DailyMed (effective June 3, 2026, Eli Lilly and Company).
What does the rifampin label say about tadalafil?
Rifampin's label (effective February 11, 2026) does not name tadalafil in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (rifampin), Lupin Pharmaceuticals, Inc., effective February 11, 2026 (SPL set b56004f0-f23d-47f6-80c7-39884fccbccc), via openFDA; the full label on DailyMed
What does the tadalafil label say about rifampin?
Tadalafil label, drug interactionsCIALIS for use as needed: no more than 10 mg every 72 hours CIALIS for once daily use: dose not to exceed 2.5 mg CYP3A4 inducers (e.g. rifampin) decrease CIALIS exposure ( 7.2 ).
Adcirca label (United Therapeutics Corporation, December 15, 2025), drug interactionsPotent Inducers of CYP3A For patients chronically taking potent inducers of CYP3A, such as rifampin, avoid use of ADCIRCA [see Clinical Pharmacology ( 12.3 )].
Source: FDA drug label (Adcirca, NDA022332), United Therapeutics Corporation, effective December 15, 2025 (SPL set ff61b237-be8e-461b-8114-78c52a8ad0ae), via openFDA
Source: FDA drug label (Tadliq, NDA214522), CMP Pharma, Inc., effective October 15, 2022 (SPL set 7a909b25-3772-403e-a5fe-e4a040293fb7), via openFDA
Source: FDA drug label (Cialis), Eli Lilly and Company, effective June 3, 2026 (SPL set bcd8f8ab-81a2-4891-83db-24a0b0e25895), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Rifampin | Tadalafil | |
|---|---|---|
| Labeled for | n/a | Erectile dysfunction, Enlarged prostate (BPH), Pulmonary arterial hypertension |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.679 per capsule 300 mg capsule | $0.167 per tablet 20 mg tablet |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once