What the FDA labels say about taking them together
Itraconazole and tadalafil
Itraconazole's FDA label of July 13, 2026 names tadalafil in its drug interactions section, and tadalafil's label names itraconazole too. The itraconazole label: “Aliskiren Riociguat Sildenafil Tadalafil Not recommended during and 2 weeks after TOLSURA treatment.”
Check it at the source: the itraconazole FDA label on DailyMed (effective July 13, 2026, Janssen Pharmaceuticals, Inc.); the tadalafil FDA label on DailyMed (effective June 3, 2026, Eli Lilly and Company).
What does the itraconazole label say about tadalafil?
Itraconazole label, drug interactionsAliskiren Riociguat Sildenafil (for pulmonary hypertension) Tadalafil (for pulmonary hypertension) Not recommended during and 2 weeks after SPORANOX ® treatment.
Source: FDA drug label (Tolsura, NDA208901), Mayne Pharma Commercial LLC, effective April 23, 2025 (SPL set 306352d1-9d5a-49ad-b72d-893b99546861), via openFDA
Source: FDA drug label (SPORANOX), Janssen Pharmaceuticals, Inc., effective July 13, 2026 (SPL set a4d555fa-787c-40fb-bb7d-b0d4f7318fd0), via openFDA; the full label on DailyMed
What does the tadalafil label say about itraconazole?
Tadalafil label, drug interactionsAlthough specific interactions have not been studied, other CYP3A4 inhibitors, such as erythromycin, itraconazole, and grapefruit juice, would likely increase tadalafil exposure.
Tadalafil label, warnings and precautionsThe dose of CIALIS for use as needed should be limited to 10 mg no more than once every 72 hours in patients taking potent inhibitors of CYP3A4 such as ritonavir, ketoconazole, and itraconazole [see Drug Interactions ( 7.2 )].
Adcirca label (United Therapeutics Corporation, December 15, 2025), drug interactionsIn patients taking potent inhibitors of CYP3A such as ketoconazole, and itraconazole, avoid use of ADCIRCA [see Clinical Pharmacology ( 12.3 )].
Source: FDA drug label (Adcirca, NDA022332), United Therapeutics Corporation, effective December 15, 2025 (SPL set ff61b237-be8e-461b-8114-78c52a8ad0ae), via openFDA
Source: FDA drug label (Tadliq, NDA214522), CMP Pharma, Inc., effective October 15, 2022 (SPL set 7a909b25-3772-403e-a5fe-e4a040293fb7), via openFDA
Source: FDA drug label (Cialis), Eli Lilly and Company, effective June 3, 2026 (SPL set bcd8f8ab-81a2-4891-83db-24a0b0e25895), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Itraconazole | Tadalafil | |
|---|---|---|
| Labeled for | Fungal infections | Erectile dysfunction, Enlarged prostate (BPH), Pulmonary arterial hypertension |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.910 per capsule 100 mg capsule | $0.167 per tablet 20 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once