What the FDA labels say about taking them together
Prednisone and tacrolimus
Tacrolimus's FDA label of July 17, 2026 names prednisone in its drug interactions section; the prednisone label PlainMeds reads does not name tacrolimus. The tacrolimus label: “Mild or Moderate CYP3A Inducers Methylprednisolone, prednisone May decrease tacrolimus whole blood trough concentrations.”
Check it at the source: the prednisone FDA label on DailyMed (effective April 22, 2025, Hikma Pharmaceuticals USA Inc.); the tacrolimus FDA label on DailyMed (effective July 17, 2026, Stellon Biotech Inc.).
What does the prednisone label say about tacrolimus?
Prednisone's label (effective April 22, 2025) does not name tacrolimus in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (PredniSONE), Hikma Pharmaceuticals USA Inc., effective April 22, 2025 (SPL set 3115aef0-fd50-4ec8-a064-3effb695f3f2), via openFDA; the full label on DailyMed
What does the tacrolimus label say about prednisone?
Tacrolimus label, drug interactionsMild or Moderate CYP3A Inducers Methylprednisolone, prednisone May decrease tacrolimus whole blood trough concentrations.
Source: FDA drug label (Envarsus Xr, NDA206406), Veloxis Pharmaceuticals, Inc, effective February 26, 2025 (SPL set de2315b0-6344-43ac-9aea-3e3b68d828e7), via openFDA
Source: FDA drug label (Tacrolimus), Stellon Biotech Inc., effective July 17, 2026 (SPL set 6b89e8a4-9f11-42e3-8e79-fe617e7c461f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Prednisone | Tacrolimus | |
|---|---|---|
| Labeled for | Osteoarthritis, Asthma, Allergies, Herpes and shingles, Leukemia, lymphoma and myeloma, Crohn's disease and ulcerative colitis, Multiple sclerosis, Eczema (atopic dermatitis), Anemia, Organ transplant rejection | Organ transplant rejection, Eczema (atopic dermatitis) |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0643 per tablet 20 mg tablet | $0.970 per gram 0.1% ointment |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once