Midazolam · more major-labeled pairs than Tacrolimus Topical
SPL labels Tacrolimus Topical + Midazolam as minor; Tacrolimus Topical 6 / Midazolam 27 in that band.
Mechanism on file: Both drugs use the same pathway in the liver to leave the body, so taking them together can interfere with how they are processed.
FDA SPL severity: Minor
Tacrolimus Topical + Midazolam · SPL mechanism field
Both drugs use the same pathway in the liver to leave the body, so taking them together can interfere with how they are processed.
Minor band excerpt · Tacrolimus Topical with Midazolam
Strong CYP3A Inducers Strong CYP3A inhibitor/inducer, based on reported effect on exposures to tacrolimus along with supporting in vitro CYP3A inhibitor/inducer data, or based on drug-drug interaction studies with midazolam (sensitive CYP3A probe substrate).
Tacrolimus Topical · 6 minor + 25 total pairs
- Cannabidiol minor
- Caspofungin minor
- Cyclosporine minor
- Methylprednisolone minor
Midazolam · 3 major-labeled pairs (vs Tacrolimus Topical's 0)
- Atomoxetine minor
- Atropine minor
- Bictegravir/Emtricitabine/Tenofovir minor
- Carbamazepine minor
FDA Drug Labels (SPL) via openFDA. Registry display only. Not medical advice.
Read our methodology - how this data is sourced, computed, and verified.