What the FDA labels say about taking them together
Metoclopramide and tacrolimus
Metoclopramide's FDA label of May 18, 2026 names tacrolimus in its drug interactions section, and tacrolimus's label names metoclopramide too. The tacrolimus label: “Monitor tacrolimus whole blood trough concentrations and reduce ENVARSUS XR dose if needed.”
Check it at the source: the metoclopramide FDA label on DailyMed (effective May 18, 2026, ANI Pharmaceuticals, Inc.); the tacrolimus FDA label on DailyMed (effective July 17, 2026, Stellon Biotech Inc.).
What does the metoclopramide label say about tacrolimus?
Metoclopramide label, drug interactions… reduced therapeutic effect of the interacting drug. For digoxin monitor therapeutic drug concentrations and increase the digoxin dose as needed (see prescribing information for digoxin). Drugs with Increased Absorption (e.g., sirolimus, tacrolimus, cyclosporine): Monitor therapeutic drug concentrations and adjust the dose as needed. See prescribing information for the interacting drug.
Gimoti label (Evoke Pharma, Inc., February 20, 2026), drug interactionsIntervention; Drugs with Decreased Absorption (e.g., digoxin, atovaquone, posaconazole oral suspension Interaction does not apply to posaconazole delayed-release tablet., fosfomycin): Monitor for reduced therapeutic effect of the interacting drug. For digoxin, monitor therapeutic drug concentrations and increase the digoxin dose as needed (see prescribing information for digoxin). Drugs with Increased Absorption (e.g., sirolimus, tacrolimus, cyclosporine): Monitor therapeutic drug concentrations and adjust the dose as needed. See prescribing information for the interacting drug.
Source: FDA drug label (Gimoti, NDA209388), Evoke Pharma, Inc., effective February 20, 2026 (SPL set 95269b1f-779c-4ca0-9f86-e74e677f9900), via openFDA
Source: FDA drug label (Metoclopramide), NDA017854 (Ani Pharms), as published by ANI Pharmaceuticals, Inc., effective May 18, 2026 (SPL set 797aad80-0597-42f8-99d5-39de180c3b5a), via openFDA; the full label on DailyMed
What does the tacrolimus label say about metoclopramide?
Tacrolimus label, drug interactionsDrug/Substance Class or Name: Other drugs, such as: Magnesium and aluminum hydroxide antacids Metoclopramide; Drug Interaction Effect: May increase tacrolimus whole blood trough concentrations and increase the risk of serious adverse reactions (e.g., neurotoxicity, QT prolongation) [see,,)].; Recommendations: Monitor tacrolimus whole blood trough concentrations and reduce tacrolimus dose if needed [ see,) and ].
Source: FDA drug label (Envarsus Xr, NDA206406), Veloxis Pharmaceuticals, Inc, effective February 26, 2025 (SPL set de2315b0-6344-43ac-9aea-3e3b68d828e7), via openFDA
Source: FDA drug label (Tacrolimus), Stellon Biotech Inc., effective July 17, 2026 (SPL set 6b89e8a4-9f11-42e3-8e79-fe617e7c461f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Metoclopramide | Tacrolimus | |
|---|---|---|
| Labeled for | Acid reflux and ulcers, Nausea and vomiting | Organ transplant rejection, Eczema (atopic dermatitis) |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0439 per tablet 10 mg tablet | $0.970 per gram 0.1% ointment |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once