What the FDA labels say about taking them together
Caspofungin and tacrolimus
Caspofungin's FDA label of October 11, 2024 names tacrolimus in its drug interactions section, and tacrolimus's label names caspofungin too. The tacrolimus label: “Caspofungin May decrease tacrolimus whole blood trough concentrations.”
Check it at the source: the caspofungin FDA label on DailyMed (effective October 11, 2024, Merck Sharp & Dohme LLC); the tacrolimus FDA label on DailyMed (effective July 17, 2026, Stellon Biotech Inc.).
What does the caspofungin label say about tacrolimus?
Caspofungin label, drug interactionsFor patients receiving CANCIDAS and tacrolimus, standard monitoring of tacrolimus trough whole blood concentrations and appropriate tacrolimus dosage adjustments are recommended.
Source: FDA drug label (Caspofungin Acetate, NDA206110), Fresenius Kabi USA, LLC, effective January 8, 2026 (SPL set e76d8d83-3691-451c-a32c-d91448c54d16), via openFDA
Source: FDA drug label (CANCIDAS), Merck Sharp & Dohme LLC, effective October 11, 2024 (SPL set 3bad23a6-09a6-4194-9182-093ed61bc71c), via openFDA; the full label on DailyMed
What does the tacrolimus label say about caspofungin?
Tacrolimus label, drug interactionsCaspofungin May decrease tacrolimus whole blood trough concentrations.
Source: FDA drug label (Tacrolimus), Stellon Biotech Inc., effective July 17, 2026 (SPL set 6b89e8a4-9f11-42e3-8e79-fe617e7c461f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Caspofungin | Tacrolimus | |
|---|---|---|
| Labeled for | Fungal infections | Organ transplant rejection, Eczema (atopic dermatitis) |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.970 per gram 0.1% ointment |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once