What the FDA labels say about taking them together
Cannabidiol and tacrolimus
Cannabidiol's FDA label of May 29, 2026 names tacrolimus in its drug interactions section, and tacrolimus's label names cannabidiol too. The tacrolimus label: “… for tacrolimus should be considered when tacrolimus is co-administered with cannabidiol.”
Check it at the source: the cannabidiol FDA label on DailyMed (effective May 29, 2026, Jazz Pharmaceuticals, Inc.); the tacrolimus FDA label on DailyMed (effective July 17, 2026, Stellon Biotech Inc.).
What does the cannabidiol label say about tacrolimus?
Cannabidiol label, drug interactionsIncreases in exposure of other orally administered P‑gp substrates (e.g., sirolimus, tacrolimus, digoxin) may be observed when concomitantly used with EPIDIOLEX.
Source: FDA drug label (Epidiolex), Jazz Pharmaceuticals, Inc., effective May 29, 2026 (SPL set 8bf27097-4870-43fb-94f0-f3d0871d1eec), via openFDA; the full label on DailyMed
What does the tacrolimus label say about cannabidiol?
Tacrolimus label, drug interactionsDecreased tacrolimus concentrations; monitor concentrations and adjust tacrolimus dose as needed. ( 5.11 , 7.2 ) Therapeutic drug monitoring and dose reduction for tacrolimus should be considered when tacrolimus is co-administered with cannabidiol ( 5.17 , 7.3 ).
Tacrolimus label, warnings and precautionsWhen cannabidiol and tacrolimus are co-administered, closely monitor for an increase in tacrolimus blood levels and for adverse reactions suggestive of tacrolimus toxicity.
Prograf label (Astellas Pharma US, Inc., August 25, 2023), drug interactionsTherapeutic drug monitoring and dose reduction for PROGRAF should be considered when PROGRAF is co-administered with cannabidiol ( 5.17 , 7.3 ).
Source: FDA drug label (Prograf, NDA050708), Astellas Pharma US, Inc., effective August 25, 2023 (SPL set 7f667de1-9dfa-4bd6-8ba0-15ee2d78873b), via openFDA
Source: FDA drug label (Tacrolimus), Stellon Biotech Inc., effective July 17, 2026 (SPL set 6b89e8a4-9f11-42e3-8e79-fe617e7c461f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cannabidiol | Tacrolimus | |
|---|---|---|
| Labeled for | n/a | Organ transplant rejection, Eczema (atopic dermatitis) |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.970 per gram 0.1% ointment |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once