What the FDA labels say about taking them together
Tacrolimus and tigecycline
Tigecycline's FDA label of November 18, 2025 names tacrolimus in its drug interactions section; the tacrolimus labels PlainMeds reads (4) do not name tigecycline. The tigecycline label: “Serum concentrations of calcineurin inhibitors should be monitored during treatment with tigecycline for injection due to risk of toxicity.”
Check it at the source: the tacrolimus FDA label on DailyMed (effective July 17, 2026, Stellon Biotech Inc.); the tigecycline FDA label on DailyMed (effective November 18, 2025, Wyeth Pharmaceuticals LLC, a subsidiary of Pfizer Inc.).
What does the tacrolimus label say about tigecycline?
Tacrolimus's label (effective July 17, 2026) and its 3 other brand-application labels do not name tigecycline in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Tacrolimus), Stellon Biotech Inc., effective July 17, 2026 (SPL set 6b89e8a4-9f11-42e3-8e79-fe617e7c461f), via openFDA; the full label on DailyMed
What does the tigecycline label say about tacrolimus?
Tigecycline label, drug interactionsCalcineurin Inhibitors: Serum concentrations of calcineurin inhibitors (e.g., tacrolimus, cyclosporine) should be monitored during treatment with TYGACIL due to risk of toxicity.
Source: FDA drug label (Tigecycline, NDA211158), Amneal Pharmaceuticals LLC, effective December 17, 2024 (SPL set 8450bd15-2b06-4fc7-b302-9021312e3f0d), via openFDA
Source: FDA drug label (Tygacil), NDA021821 (Pf Prism Cv), as published by Wyeth Pharmaceuticals LLC, a subsidiary of Pfizer Inc., effective November 18, 2025 (SPL set fd826e47-1b77-4ffd-bb22-fda3379903b0), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Tacrolimus | Tigecycline | |
|---|---|---|
| Labeled for | Organ transplant rejection, Eczema (atopic dermatitis) | Bacterial infections |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.970 per gram 0.1% ointment | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once