What the FDA labels say about taking them together
Cyclosporine and sulindac
Cyclosporine's FDA label of August 10, 2026 names sulindac in its drug interactions section, and sulindac's label names cyclosporine too. The sulindac label: “Cyclosporine Administration of non-steroidal anti-inflammatory drugs concomitantly with cyclosporine has been associated with an increase in cyclosporine-induced toxicity, possibly due to decreased synthesis of renal …”
Check it at the source: the cyclosporine FDA label on DailyMed (effective August 10, 2026, Novartis Pharmaceuticals Corporation); the sulindac FDA label on DailyMed (effective December 20, 2024, Epic Pharma, LLC).
What does the cyclosporine label say about sulindac?
Cyclosporine label, drug interactionsvancomycin; sulindac
Source: FDA drug label (Neoral), Novartis Pharmaceuticals Corporation, effective August 10, 2026 (SPL set 94461af3-11f1-4670-95d4-2965b9538ae3), via openFDA; the full label on DailyMed
What does the sulindac label say about cyclosporine?
Sulindac label, drug interactionsCyclosporine Administration of non-steroidal anti-inflammatory drugs concomitantly with cyclosporine has been associated with an increase in cyclosporine-induced toxicity, possibly due to decreased synthesis of renal prostacyclin.
Source: FDA drug label (SULINDAC), Epic Pharma, LLC, effective December 20, 2024 (SPL set 96c73bd2-4577-487d-a642-bd8f91e94c3a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cyclosporine | Sulindac | |
|---|---|---|
| Labeled for | Organ transplant rejection, Rheumatoid arthritis | Osteoarthritis, Rheumatoid arthritis |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $1.04 per unit 0.05% eye emulsion | $0.189 per tablet 150 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once