What the FDA labels say about taking them together
Sulfamethoxazole/trimethoprim and zidovudine
Sulfamethoxazole/trimethoprim's FDA label of December 30, 2024 names zidovudine in its drug interactions section; the zidovudine labels PlainMeds reads (3) do not name sulfamethoxazole/trimethoprim. The sulfamethoxazole/trimethoprim label: “Zidovudine Monitor for hematologic toxicity Zidovudine and BACTRIM are known to induce hematological abnormalities.”
Check it at the source: the sulfamethoxazole/trimethoprim FDA label on DailyMed (effective December 30, 2024, Sun Pharmaceutical Industries, Inc); the zidovudine FDA label on DailyMed (effective February 10, 2025, Aurobindo Pharma Limited).
What does the sulfamethoxazole/trimethoprim label say about zidovudine?
Sulfamethoxazole/trimethoprim label, drug interactionsZidovudine Monitor for hematologic toxicity Zidovudine and BACTRIM are known to induce hematological abnormalities.
Source: FDA drug label (Bactrim), Sun Pharmaceutical Industries, Inc, effective December 30, 2024 (SPL set f59d0c04-9c66-4d53-a0e1-cb55570deb62), via openFDA; the full label on DailyMed
What does the zidovudine label say about sulfamethoxazole/trimethoprim?
Zidovudine's label (effective February 10, 2025) and its 2 other brand-application labels do not name sulfamethoxazole/trimethoprim in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Zidovudine), Aurobindo Pharma Limited, effective February 10, 2025 (SPL set 51abd2ce-6be1-412d-b806-5f24935ac5e3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Sulfamethoxazole/trimethoprim | Zidovudine | |
|---|---|---|
| Labeled for | Bacterial infections, Urinary tract infections, Diarrhea | HIV |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0448 per tablet Sulfamethoxazole-tmp ds tablet | $0.464 per tablet 300 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once