What the FDA labels say about taking them together
Spironolactone and triamterene
Triamterene's FDA label of December 5, 2024 names spironolactone in its contraindications section; the spironolactone labels PlainMeds reads (2) do not name triamterene.
Check it at the source: the spironolactone FDA label on DailyMed (effective November 28, 2025, Pfizer Laboratories Div Pfizer Inc); the triamterene FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.).
What does the spironolactone label say about triamterene?
Spironolactone's label (effective November 28, 2025) and its 1 other brand-application label do not name triamterene in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Aldactone), Pfizer Laboratories Div Pfizer Inc, effective November 28, 2025 (SPL set 0fed2822-3a03-4b64-9857-c682fcd462bc), via openFDA; the full label on DailyMed
What does the triamterene label say about spironolactone?
Triamterene label, contraindicationsDyrenium should not be given to patients receiving other potassium-sparing agents, such as spironolactone, amiloride hydrochloride, or other formulations containing triamterene.
Source: FDA drug label (Dyrenium), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set ebb177c0-d45d-4443-a85a-e76bd9931a42), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Spironolactone | Triamterene | |
|---|---|---|
| Labeled for | Heart failure, Edema (fluid retention), High blood pressure | Heart failure, Edema (fluid retention) |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0426 per tablet 25 mg tablet | $5.98 per capsule 50 mg capsule |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once