What the FDA labels say about taking them together
Sotalol and tolterodine
Tolterodine's FDA label of February 9, 2026 names sotalol in its warnings and precautions section; the sotalol labels PlainMeds reads (3) do not name tolterodine. The tolterodine label: “Advise patients not to drive or operate heavy machinery until they know how tolterodine tartrate extended-release capsules affect them. Myasthenia Gravis: use caution in patients with myasthenia gravis. …”
Check it at the source: the sotalol FDA label on DailyMed (effective December 16, 2024, Legacy Pharma USA, Inc.); the tolterodine FDA label on DailyMed (effective February 9, 2026, Torrent Pharmaceuticals Limited).
What does the sotalol label say about tolterodine?
Sotalol's label (effective December 16, 2024) and its 2 other brand-application labels do not name tolterodine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (BETAPACE), Legacy Pharma USA, Inc., effective December 16, 2024 (SPL set a6a7702f-36c9-45db-b640-453dc324baee), via openFDA; the full label on DailyMed
What does the tolterodine label say about sotalol?
Tolterodine label, warnings and precautionsAdvise patients not to drive or operate heavy machinery until they know how tolterodine tartrate extended-release capsules affect them. ( 5.5 ) Myasthenia Gravis: use caution in patients with myasthenia gravis. ( 5.8 ) QT Prolongation: consider observations from the thorough QT study in clinical decisions to prescribe tolterodine tartrate extended-release capsules to patients with a known history of QT prolongation or to patients who are taking Class IA (e.g., quinidine, procainamide) or Class III (e.g., amiodarone, sotalol) antiarrhythmic medications.
Source: FDA drug label (TOLTERODINE TARTRATE), Torrent Pharmaceuticals Limited, effective February 9, 2026 (SPL set db6e0b6d-0ce5-41d7-881f-881c11f530a4), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Sotalol | Tolterodine | |
|---|---|---|
| Labeled for | Atrial fibrillation | Overactive bladder |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0707 per tablet 80 mg tablet | $0.268 per capsule 2 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once