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What the FDA labels say about taking them together

Sotalol and terbutaline

Sotalol's FDA label of December 16, 2024 names terbutaline in its drug interactions section; the terbutaline label PlainMeds reads does not name sotalol. The sotalol label: “Beta-2-Receptor Stimulants Beta-agonists such as albuterol, terbutaline and isoproterenol may have to be administered in increased dosages when used concomitantly with sotalol.”

Check it at the source: the sotalol FDA label on DailyMed (effective December 16, 2024, Legacy Pharma USA, Inc.); the terbutaline FDA label on DailyMed (effective November 15, 2019, ANI Pharmaceuticals, Inc.).

What does the sotalol label say about terbutaline?

Sotalol label, drug interactions

Beta-2-Receptor Stimulants Beta-agonists such as albuterol, terbutaline and isoproterenol may have to be administered in increased dosages when used concomitantly with sotalol.

Source: FDA drug label (BETAPACE), Legacy Pharma USA, Inc., effective December 16, 2024 (SPL set a6a7702f-36c9-45db-b640-453dc324baee), via openFDA; the full label on DailyMed

What does the terbutaline label say about sotalol?

Terbutaline's label (effective November 15, 2019) does not name sotalol in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (Terbutaline Sulfate), NDA017849 (Ani Pharms), as published by ANI Pharmaceuticals, Inc., effective November 15, 2019 (SPL set d810a15b-3e10-4f6c-a36e-8ddecbaba9c3), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

18Sotalol generic labelers
9Terbutaline generic labelers
SotalolTerbutaline
Labeled forAtrial fibrillationn/a
Boxed warningYesYes
Pharmacy cost (NADAC)$0.0707 per tablet 80 mg tablet$0.947 per tablet 2.5 mg tablet
Shortage nowNo current entryNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?