What the FDA labels say about taking them together
Sofosbuvir/velpatasvir/voxilaprevir and topotecan
Sofosbuvir/velpatasvir/voxilaprevir's FDA label of July 14, 2025 names topotecan in its drug interactions section; the topotecan labels PlainMeds reads (3) do not name sofosbuvir/velpatasvir/voxilaprevir. The sofosbuvir/velpatasvir/voxilaprevir label: “Coadministration of VOSEVI with BCRP substrates is not recommended.”
Check it at the source: the sofosbuvir/velpatasvir/voxilaprevir FDA label on DailyMed (effective July 14, 2025, Gilead Sciences, Inc.); the topotecan FDA label on DailyMed (effective July 7, 2022, Novartis Pharmaceuticals Corporation).
What does the sofosbuvir/velpatasvir/voxilaprevir label say about topotecan?
Sofosbuvir/velpatasvir/voxilaprevir label, drug interactionsCoadministration of VOSEVI with BCRP substrates (e.g., methotrexate, mitoxantrone, imatinib, irinotecan, lapatinib, rosuvastatin, sulfasalazine, topotecan) is not recommended [see Clinical Pharmacology (12.3) ].
Source: FDA drug label (Vosevi), Gilead Sciences, Inc., effective July 14, 2025 (SPL set 17ffc094-8ca7-45d2-80d8-fd043bc9a221), via openFDA; the full label on DailyMed
What does the topotecan label say about sofosbuvir/velpatasvir/voxilaprevir?
Topotecan's label (effective July 7, 2022) and its 2 other brand-application labels do not name sofosbuvir/velpatasvir/voxilaprevir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (HYCAMTIN), NDA020671 (Sandoz), as published by Novartis Pharmaceuticals Corporation, effective July 7, 2022 (SPL set eeee060c-a9ec-423e-a374-8484009f8524), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Sofosbuvir/velpatasvir/voxilaprevir | Topotecan | |
|---|---|---|
| Labeled for | Hepatitis C | Lung cancer |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once