What the FDA labels say about taking them together
Sodium polystyrene sulfonate and tenapanor
Tenapanor's FDA label of June 27, 2025 names sodium polystyrene sulfonate in its drug interactions section; the sodium polystyrene sulfonate label PlainMeds reads does not name tenapanor.
Check it at the source: the sodium polystyrene sulfonate FDA label on DailyMed (effective November 29, 2023, Epic Pharma, LLC); the tenapanor FDA label on DailyMed (effective June 27, 2025, Ardelyx, Inc.).
What does the sodium polystyrene sulfonate label say about tenapanor?
Sodium polystyrene sulfonate's label (effective November 29, 2023) does not name tenapanor in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Sodium Polystyrene Sulfonate), Epic Pharma, LLC, effective November 29, 2023 (SPL set 61cc890b-eb3d-494c-ae45-629a27e721ce), via openFDA; the full label on DailyMed
What does the tenapanor label say about sodium polystyrene sulfonate?
Tenapanor label, drug interactionsSodium Polystyrene Sulfonate (SPS): Separate administration by at least three hours ( 7.2 ).
Source: FDA drug label (XPHOZAH 10 mg), Ardelyx, Inc., effective June 27, 2025 (SPL set c57e279c-0f1b-4238-81b7-4e0dc0cc60c5), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Sodium polystyrene sulfonate | Tenapanor | |
|---|---|---|
| Labeled for | n/a | Irritable bowel syndrome, Constipation |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.155 per gram Sodium polystyrene sulf powder | $32.54 per tablet 50 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once