What the FDA labels say about taking them together
Sodium nitroprusside and sodium thiosulfate
Sodium nitroprusside's FDA label of August 10, 2026 names sodium thiosulfate in its warnings section; the sodium thiosulfate labels PlainMeds reads (2) do not name sodium nitroprusside. The sodium nitroprusside label: “Cyanide Toxicity: As described in CLINICAL PHARMACOLOGY above, sodium nitroprusside infusions at rates above 2 mcg/kg/min generate cyanide ion (CN¯) faster than the body can normally dispose of it. …”
Check it at the source: the sodium nitroprusside FDA label on DailyMed (effective August 10, 2026, Micro Labs Limited); the sodium thiosulfate FDA label on DailyMed (effective May 26, 2026, Hope Pharmaceuticals).
What does the sodium nitroprusside label say about sodium thiosulfate?
Sodium nitroprusside label, warningsCyanide Toxicity: As described in CLINICAL PHARMACOLOGY above, sodium nitroprusside infusions at rates above 2 mcg/kg/min generate cyanide ion (CN¯) faster than the body can normally dispose of it. (When sodium thiosulfate is given, as described under DOSAGE AND ADMINISTRATION , the body’s capacity for CN¯ elimination is greatly increased.) Methemoglobin normally present in the body can buffer a certain amount of CN¯, but the capacity of this system is exhausted by the CN¯ produced from about 500 mcg/kg of sodium nitroprusside.
Source: FDA drug label (SODIUM NITROPRUSSIDE), Micro Labs Limited, effective August 10, 2026 (SPL set 5a599880-c133-44ef-a9f2-bd1b681563be), via openFDA; the full label on DailyMed
What does the sodium thiosulfate label say about sodium nitroprusside?
Sodium thiosulfate's label (effective May 26, 2026) and its 1 other brand-application label do not name sodium nitroprusside in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Sodium Thiosulfate), Hope Pharmaceuticals, effective May 26, 2026 (SPL set 82f55408-2de9-463d-85e8-b39c3b259f0b), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Sodium nitroprusside | Sodium thiosulfate | |
|---|---|---|
| Labeled for | Heart failure | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once