What the FDA labels say about taking them together
Siponimod and sotalol
Siponimod's FDA label of June 30, 2026 names sotalol in its drug interactions section; the sotalol labels PlainMeds reads (3) do not name siponimod.
Check it at the source: the siponimod FDA label on DailyMed (effective June 30, 2026, Novartis Pharmaceuticals Corporation); the sotalol FDA label on DailyMed (effective December 16, 2024, Legacy Pharma USA, Inc.).
What does the siponimod label say about sotalol?
Siponimod label, drug interactionsClass Ia (e.g., quinidine, procainamide) and Class III (e.g., amiodarone, sotalol) antiarrhythmic drugs have been associated with cases of Torsades de Pointes in patients with bradycardia.
Source: FDA drug label (MAYZENT), Novartis Pharmaceuticals Corporation, effective June 30, 2026 (SPL set 44492772-5aed-4627-bd85-e8e89f308bb3), via openFDA; the full label on DailyMed
What does the sotalol label say about siponimod?
Sotalol's label (effective December 16, 2024) and its 2 other brand-application labels do not name siponimod in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (BETAPACE), Legacy Pharma USA, Inc., effective December 16, 2024 (SPL set a6a7702f-36c9-45db-b640-453dc324baee), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Siponimod | Sotalol | |
|---|---|---|
| Labeled for | Multiple sclerosis | Atrial fibrillation |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.0707 per tablet 80 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once