What the FDA labels say about taking them together
Simvastatin and tocilizumab
Tocilizumab's FDA label of December 16, 2025 names simvastatin in its drug interactions section; the simvastatin label PlainMeds reads does not name tocilizumab. The tocilizumab label: “In vivo studies with omeprazole, metabolized by CYP2C19 and CYP3A4, and simvastatin, metabolized by CYP3A4, showed up to a 28% and 57% decrease in exposure one week following a single dose of ACTEMRA, respectively.”
Check it at the source: the simvastatin FDA label on DailyMed (effective March 28, 2025, Organon LLC); the tocilizumab FDA label on DailyMed (effective December 16, 2025, Genentech, Inc.).
What does the simvastatin label say about tocilizumab?
Simvastatin's label (effective March 28, 2025) does not name tocilizumab in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (ZOCOR), Organon LLC, effective March 28, 2025 (SPL set 8f55d5de-5a4f-4a39-8c84-c53976dd6af9), via openFDA; the full label on DailyMed
What does the tocilizumab label say about simvastatin?
Tocilizumab label, drug interactionsIn vivo studies with omeprazole, metabolized by CYP2C19 and CYP3A4, and simvastatin, metabolized by CYP3A4, showed up to a 28% and 57% decrease in exposure one week following a single dose of ACTEMRA, respectively.
Source: FDA drug label (Avtozma, BLA761420), CELLTRION USA, Inc., effective July 27, 2026 (SPL set 581c288f-8015-40ef-a4c3-683c96db193d), via openFDA
Source: FDA drug label (ACTEMRA), Genentech, Inc., effective December 16, 2025 (SPL set 2e5365ff-cb2a-4b16-b2c7-e35c6bf2de13), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Simvastatin | Tocilizumab | |
|---|---|---|
| Labeled for | Heart attack and coronary artery disease, High cholesterol, High triglycerides | Rheumatoid arthritis, COVID-19 |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0321 per tablet 20 mg tablet | $821.00 per mL 162 mg/0.9 mL autoinjct |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once