What the FDA labels say about taking them together
Simvastatin and teriflunomide
Teriflunomide's FDA label of February 20, 2026 names simvastatin in its drug interactions section; the simvastatin label PlainMeds reads does not name teriflunomide. The teriflunomide label: “For other substrates of BCRP (e.g., mitoxantrone) and drugs in the OATP family, especially HMG-Co reductase inhibitors, consider reducing the dose of these drugs and monitor patients closely for signs and symptoms of …”
Check it at the source: the simvastatin FDA label on DailyMed (effective March 28, 2025, Organon LLC); the teriflunomide FDA label on DailyMed (effective February 20, 2026, Genzyme Corporation).
What does the simvastatin label say about teriflunomide?
Simvastatin's label (effective March 28, 2025) does not name teriflunomide in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (ZOCOR), Organon LLC, effective March 28, 2025 (SPL set 8f55d5de-5a4f-4a39-8c84-c53976dd6af9), via openFDA; the full label on DailyMed
What does the teriflunomide label say about simvastatin?
Teriflunomide label, drug interactionsFor other substrates of BCRP (e.g., mitoxantrone) and drugs in the OATP family (e.g., methotrexate, rifampin), especially HMG-Co reductase inhibitors (e.g., atorvastatin, nateglinide, pravastatin, repaglinide, and simvastatin), consider reducing the dose of these drugs and monitor patients closely for signs and symptoms of increased exposures to the drugs while patients are taking AUBAGIO [see Clinical Pharmacology (12.3) ].
Source: FDA drug label (Aubagio), NDA202992 (Sanofi Aventis Us), as published by Genzyme Corporation, effective February 20, 2026 (SPL set 4650d12c-b9c8-4525-b07f-a2d773eca155), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Simvastatin | Teriflunomide | |
|---|---|---|
| Labeled for | Heart attack and coronary artery disease, High cholesterol, High triglycerides | Multiple sclerosis |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0321 per tablet 20 mg tablet | $0.233 per tablet 14 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once