What the FDA labels say about taking them together
Sildenafil and sodium nitroprusside
Sildenafil's FDA label of November 17, 2023 names sodium nitroprusside in its warnings and precautions section, and sodium nitroprusside's label names sildenafil too. The sodium nitroprusside label: “Acute heart failure associated with reduced peripheral vascular resistance. Concomitant use with sildenafil, tadalafil, vardenifil, or riociguat.”
Check it at the source: the sildenafil FDA label on DailyMed (effective November 17, 2023, Viatris Specialty LLC); the sodium nitroprusside FDA label on DailyMed (effective August 10, 2026, Micro Labs Limited).
What does the sildenafil label say about sodium nitroprusside?
Sildenafil label, warnings and precautionsHowever, in vitro studies with human platelets indicate that sildenafil potentiates the antiaggregatory effect of sodium nitroprusside (a nitric oxide donor).
Source: FDA drug label (Viagra), Viatris Specialty LLC, effective November 17, 2023 (SPL set d905dc8d-917f-4ea3-a4ee-a1ecf6967d4e), via openFDA; the full label on DailyMed
What does the sodium nitroprusside label say about sildenafil?
Nipride Rtu label (EXELA PHARMA SCIENCES, LLC, July 20, 2018), contraindicationsAcute heart failure associated with reduced peripheral vascular resistance. Concomitant use with sildenafil, tadalafil, vardenifil, or riociguat.
Source: FDA drug label (Nipride Rtu, NDA209387), EXELA PHARMA SCIENCES, LLC, effective July 20, 2018 (SPL set 5acf0836-93ff-4064-b888-3f560e8a558d), via openFDA
Source: FDA drug label (SODIUM NITROPRUSSIDE), Micro Labs Limited, effective August 10, 2026 (SPL set 5a599880-c133-44ef-a9f2-bd1b681563be), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Sildenafil | Sodium nitroprusside | |
|---|---|---|
| Labeled for | Erectile dysfunction, Pulmonary arterial hypertension | Heart failure |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.132 per tablet 100 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once