What the FDA labels say about taking them together
Sevoflurane and succinylcholine
Sevoflurane's FDA label of February 12, 2025 names succinylcholine in its drug interactions section; the succinylcholine labels PlainMeds reads (2) do not name sevoflurane. The sevoflurane label: “The risk of developing malignant hyperthermia increases with the concomitant administration of succinylcholine and volatile anesthetic agents.”
Check it at the source: the sevoflurane FDA label on DailyMed (effective February 12, 2025, AbbVie Inc.); the succinylcholine FDA label on DailyMed (effective August 18, 2026, Hospira, Inc.).
What does the sevoflurane label say about succinylcholine?
Sevoflurane label, drug interactionsThe effect of sevoflurane on the duration of depolarizing neuromuscular blockade induced by succinylcholine has not been studied.
Sevoflurane label, warningsThe risk of developing malignant hyperthermia increases with the concomitant administration of succinylcholine and volatile anesthetic agents.
Source: FDA drug label (Ultane), AbbVie Inc., effective February 12, 2025 (SPL set c9aa6489-5a36-44ed-9512-b996833d82f7), via openFDA; the full label on DailyMed
What does the succinylcholine label say about sevoflurane?
Succinylcholine's label (effective August 18, 2026) and its 1 other brand-application label do not name sevoflurane in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (QUELICIN), Hospira, Inc., effective August 18, 2026 (SPL set fb08161e-7711-406d-e7b3-ea4515c07983), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Sevoflurane | Succinylcholine | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once