What the FDA labels say about taking them together
Sevelamer and tacrolimus
Sevelamer's FDA label of November 25, 2025 names tacrolimus in its drug interactions section; the tacrolimus labels PlainMeds reads (4) do not name sevelamer.
Check it at the source: the sevelamer FDA label on DailyMed (effective November 25, 2025, Sanofi-Aventis U.S. LLC); the tacrolimus FDA label on DailyMed (effective July 17, 2026, Stellon Biotech Inc.).
What does the sevelamer label say about tacrolimus?
Sevelamer label, drug interactionsFor oral medication where a reduction in the bioavailability of that medication would have a clinically significant effect on its safety or efficacy (e.g., cyclosporine, tacrolimus, levothyroxine), consider separation of the timing of the administration of the two drugs [see Clinical Pharmacology (12.3) ].
Source: FDA drug label (Sevelamer Carbonate), Sanofi-Aventis U.S. LLC, effective November 25, 2025 (SPL set 3abc32fe-1bfc-4759-8f7c-36095e221b06), via openFDA; the full label on DailyMed
What does the tacrolimus label say about sevelamer?
Tacrolimus's label (effective July 17, 2026) and its 3 other brand-application labels do not name sevelamer in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Tacrolimus), Stellon Biotech Inc., effective July 17, 2026 (SPL set 6b89e8a4-9f11-42e3-8e79-fe617e7c461f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Sevelamer | Tacrolimus | |
|---|---|---|
| Labeled for | n/a | Organ transplant rejection, Eczema (atopic dermatitis) |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.214 per tablet 800 mg tablet | $0.970 per gram 0.1% ointment |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once