What the FDA labels say about taking them together
Selexipag and teriflunomide
Selexipag's FDA label of May 28, 2026 names teriflunomide in its drug interactions section; the teriflunomide label PlainMeds reads does not name selexipag. The selexipag label: “DRUG INTERACTIONS Moderate CYP2C8 inhibitors increase exposure to the active metabolite of UPTRAVI.”
Check it at the source: the selexipag FDA label on DailyMed (effective May 28, 2026, Actelion Pharmaceuticals US, Inc.); the teriflunomide FDA label on DailyMed (effective February 20, 2026, Genzyme Corporation).
What does the selexipag label say about teriflunomide?
Selexipag label, drug interactionsDRUG INTERACTIONS Moderate CYP2C8 inhibitors (e.g., clopidogrel, deferasirox and teriflunomide) increase exposure to the active metabolite of UPTRAVI.
Source: FDA drug label (UPTRAVI), Actelion Pharmaceuticals US, Inc., effective May 28, 2026 (SPL set a7a23b87-f892-4e2c-8e2e-ebf841220f90), via openFDA; the full label on DailyMed
What does the teriflunomide label say about selexipag?
Teriflunomide's label (effective February 20, 2026) does not name selexipag in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Aubagio), NDA202992 (Sanofi Aventis Us), as published by Genzyme Corporation, effective February 20, 2026 (SPL set 4650d12c-b9c8-4525-b07f-a2d773eca155), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Selexipag | Teriflunomide | |
|---|---|---|
| Labeled for | Pulmonary arterial hypertension | Multiple sclerosis |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.233 per tablet 14 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once