What the FDA labels say about taking them together
Dextromethorphan and rolapitant
Rolapitant's FDA label of August 19, 2020 names dextromethorphan in its drug interactions section; the dextromethorphan label PlainMeds reads does not name rolapitant. The rolapitant label: “Exposure to dextromethorphan, a CYP2D6 substrate, following a single dose of rolapitant increased about 3-fold on Days 8 and Day 22.”
Check it at the source: the dextromethorphan FDA label on DailyMed (effective August 27, 2026); the rolapitant FDA label on DailyMed (effective August 19, 2020, TerSera Therapeutics LLC).
What does the dextromethorphan label say about rolapitant?
Dextromethorphan's label (effective August 27, 2026) does not name rolapitant in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Good Sense Cough DM), L. Perrigo Company, effective August 27, 2026 (SPL set 5a2e9bef-42cb-4b72-9a26-c3ae71dcb4ea), via openFDA; the full label on DailyMed
What does the rolapitant label say about dextromethorphan?
Rolapitant label, drug interactionsThe inhibition of CYP2D6 persisted on Day 28 with a 2.3-fold increase in dextromethorphan concentrations, the last time point measured.
Rolapitant label, warnings and precautionsExposure to dextromethorphan, a CYP2D6 substrate, following a single dose of rolapitant increased about 3-fold on Days 8 and Day 22.
Source: FDA drug label (Varubi), TerSera Therapeutics LLC, effective August 19, 2020 (SPL set a52896cd-4a98-49b8-82db-bf1985a64d97), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Dextromethorphan | Rolapitant | |
|---|---|---|
| Labeled for | Cough and cold | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.122 per unit 15 mg softgel | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once