Rolapitant and Dextromethorphan Interaction
Drug interaction information between Rolapitant and Dextromethorphan.
Rolapitant and Dextromethorphan have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Rolapitant and Dextromethorphan. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rolapitant stops a liver enzyme from breaking down dextromethorphan, which can cause the cough medicine to reach much higher levels in your body.
FDA Label Information
The inhibition of CYP2D6 persisted on Day 28 with a 2.3-fold increase in dextromethorphan concentrations, the last time point measured.
Rolapitant Also Interacts With
- Pimozide major
- Thioridazine major
- Rifampin moderate
- Rosuvastatin minor
- Warfarin minor
Dextromethorphan Also Interacts With
- Safinamide major
- Memantine moderate
- Rasagiline moderate
- Tranylcypromine moderate
- Abiraterone minor
Frequently Asked Questions
What SPL severity band is on file for Rolapitant + Dextromethorphan?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Dextromethorphan has 15 labeled pairs on file vs Rolapitant's 9. In the minor band specifically: Rolapitant has 6 (also Rosuvastatin, Warfarin, Methotrexate, Digoxin); Dextromethorphan has 11 (also Abiraterone, Aripiprazole, Brexpiprazole, Desvenlafaxine).
What mechanism field is on file for Rolapitant and Dextromethorphan?
Rolapitant stops a liver enzyme from breaking down dextromethorphan, which can cause the cough medicine to reach much higher levels in your body.
Rolapitant carries more major-labeled pairs than Dextromethorphan
SPL source-record counts only. This page's band is minor · classes on file: Rolapitant (NK1 Receptor Antagonist (Antiemetic)); Dextromethorphan (Antitussive).
Rolapitant has 2 major-labeled pairs vs Dextromethorphan's 1. This page itself is in the minor band, not the major band.
2 major · 1 moderate · 6 minor · 9 total
- Other minor peers for Rolapitant
- Rosuvastatin
- Warfarin
- Methotrexate
- Digoxin
1 major · 3 moderate · 11 minor · 15 total
- Other minor peers for Dextromethorphan
- Abiraterone
- Aripiprazole
- Brexpiprazole
- Desvenlafaxine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.