What the FDA labels say about taking them together
Fluvoxamine and roflumilast
Roflumilast's FDA label of March 12, 2020 names fluvoxamine in its drug interactions section; the fluvoxamine labels PlainMeds reads (2) do not name roflumilast. The roflumilast label: “Use with inhibitors of CYP3A4 or dual inhibitors of CYP3A4 and CYP1A2 will increase roflumilast systemic exposure and may result in increased adverse reactions.”
Check it at the source: the fluvoxamine FDA label on DailyMed (effective June 27, 2026, Zydus Pharmaceuticals USA Inc.); the roflumilast FDA label on DailyMed (effective March 12, 2020, AstraZeneca Pharmaceuticals LP).
What does the fluvoxamine label say about roflumilast?
Fluvoxamine's label (effective June 27, 2026) and its 1 other brand-application label do not name roflumilast in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Fluvoxamine maleate extended-release), Zydus Pharmaceuticals USA Inc., effective June 27, 2026 (SPL set 6c71d4f6-54b5-4d3a-8d2f-b7773c92c32e), via openFDA; the full label on DailyMed
What does the roflumilast label say about fluvoxamine?
Roflumilast label, drug interactionsUse with inhibitors of CYP3A4 or dual inhibitors of CYP3A4 and CYP1A2 (e.g., erythromycin, ketoconazole, fluvoxamine, enoxacin, cimetidine) will increase roflumilast systemic exposure and may result in increased adverse reactions.
Source: FDA drug label (Daliresp), AstraZeneca Pharmaceuticals LP, effective March 12, 2020 (SPL set c9a1d0a8-581f-4f91-a2b8-f419192d0ebf), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fluvoxamine | Roflumilast | |
|---|---|---|
| Labeled for | n/a | COPD, Psoriasis, Eczema (atopic dermatitis) |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $4.08 per capsule 100 mg capsule | $0.311 per tablet 500 mcg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once