What the FDA labels say about taking them together
Erythromycin and roflumilast
Roflumilast's FDA label of March 12, 2020 names erythromycin in its drug interactions section; the erythromycin labels PlainMeds reads (4) do not name roflumilast. The roflumilast label: “Use with inhibitors of CYP3A4 or dual inhibitors of CYP3A4 and CYP1A2 will increase roflumilast systemic exposure and may result in increased adverse reactions.”
Check it at the source: the erythromycin FDA label on DailyMed (effective August 1, 2024, Teva Pharmaceuticals USA, Inc.); the roflumilast FDA label on DailyMed (effective March 12, 2020, AstraZeneca Pharmaceuticals LP).
What does the erythromycin label say about roflumilast?
Erythromycin's label (effective August 1, 2024) and its 3 other brand-application labels do not name roflumilast in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Erythromycin), Teva Pharmaceuticals USA, Inc., effective August 1, 2024 (SPL set 75a0bd5a-d09f-483b-bfd8-f8343b149eb2), via openFDA; the full label on DailyMed
What does the roflumilast label say about erythromycin?
Roflumilast label, drug interactionsUse with inhibitors of CYP3A4 or dual inhibitors of CYP3A4 and CYP1A2 (e.g., erythromycin, ketoconazole, fluvoxamine, enoxacin, cimetidine) will increase roflumilast systemic exposure and may result in increased adverse reactions.
Source: FDA drug label (Daliresp), AstraZeneca Pharmaceuticals LP, effective March 12, 2020 (SPL set c9a1d0a8-581f-4f91-a2b8-f419192d0ebf), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Erythromycin | Roflumilast | |
|---|---|---|
| Labeled for | Bacterial infections, Acne | COPD, Psoriasis, Eczema (atopic dermatitis) |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $1.96 per tablet 250 mg tablet | $0.311 per tablet 500 mcg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once