What the FDA labels say about taking them together
Rizatriptan and tranylcypromine
Rizatriptan's FDA label of January 29, 2026 names tranylcypromine in its drug interactions section; the tranylcypromine label PlainMeds reads does not name rizatriptan. The rizatriptan label: “Plasma concentrations of rizatriptan may be increased by drugs that are selective MAO-A inhibitors (e.g., moclobemide) or nonselective MAO inhibitors [type A and B].”
Check it at the source: the rizatriptan FDA label on DailyMed (effective January 29, 2026); the tranylcypromine FDA label on DailyMed (effective July 2, 2025, Advanz Pharma (US) Corp.).
What does the rizatriptan label say about tranylcypromine?
Rizatriptan label, drug interactionsPlasma concentrations of rizatriptan may be increased by drugs that are selective MAO-A inhibitors (e.g., moclobemide) or nonselective MAO inhibitors [type A and B] (e.g., isocarboxazid, phenelzine, tranylcypromine, and pargyline).
Source: FDA drug label (MAXALT), Organon LLC, effective January 29, 2026 (SPL set 007b4644-e0e7-4863-9ae3-fe09676b3f5f), via openFDA; the full label on DailyMed
What does the tranylcypromine label say about rizatriptan?
Tranylcypromine's label (effective July 2, 2025) does not name rizatriptan in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (PARNATE), Advanz Pharma (US) Corp., effective July 2, 2025 (SPL set b72d8187-dfcc-4ea0-b5e9-c0be95b69a27), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Rizatriptan | Tranylcypromine | |
|---|---|---|
| Labeled for | Migraine | Depression |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.335 per tablet 10 mg tablet | $0.591 per tablet 10 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once