What the FDA labels say about taking them together
Riluzole and zileuton
Riluzole's FDA label of July 10, 2020 names zileuton in its drug interactions section; the zileuton labels PlainMeds reads (2) do not name riluzole. The riluzole label: “The concomitant use of strong or moderate CYP1A2 inhibitors with riluzole may increase the risk of riluzole-associated adverse reactions.”
Check it at the source: the riluzole FDA label on DailyMed (effective July 10, 2020, Glenmark Pharmaceuticals Inc., USA); the zileuton FDA label on DailyMed (effective July 29, 2022, Strides Pharma Science Limited).
What does the riluzole label say about zileuton?
Riluzole label, drug interactionsThe concomitant use of strong or moderate CYP1A2 inhibitors (e.g., ciprofloxacin, enoxacin, fluvoxamine, methoxsalen, mexiletine, oral contraceptives, thiabendazole, vemurafenib, zileuton) with riluzole may increase the risk of riluzole-associated adverse reactions [see Clinical Pharmacology ( 12.3 )].
Source: FDA drug label (riluzole), Glenmark Pharmaceuticals Inc., USA, effective July 10, 2020 (SPL set f1ce57e8-d3fe-422c-8724-3101c258898a), via openFDA; the full label on DailyMed
What does the zileuton label say about riluzole?
Zileuton's label (effective July 29, 2022) and its 1 other brand-application label do not name riluzole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Zileuton), Strides Pharma Science Limited, effective July 29, 2022 (SPL set a826d16f-df07-447b-b050-b9a02ea1f89e), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Riluzole | Zileuton | |
|---|---|---|
| Labeled for | n/a | Asthma |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.293 per tablet 50 mg tablet | $2.05 per tablet 600 mg tablet |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once