What the FDA labels say about taking them together
Riluzole and vemurafenib
Riluzole's FDA label of July 10, 2020 names vemurafenib in its drug interactions section; the vemurafenib label PlainMeds reads does not name riluzole. The riluzole label: “The concomitant use of strong or moderate CYP1A2 inhibitors with riluzole may increase the risk of riluzole-associated adverse reactions.”
Check it at the source: the riluzole FDA label on DailyMed (effective July 10, 2020, Glenmark Pharmaceuticals Inc., USA); the vemurafenib FDA label on DailyMed (effective August 28, 2026, Genentech, Inc.).
What does the riluzole label say about vemurafenib?
Riluzole label, drug interactionsThe concomitant use of strong or moderate CYP1A2 inhibitors (e.g., ciprofloxacin, enoxacin, fluvoxamine, methoxsalen, mexiletine, oral contraceptives, thiabendazole, vemurafenib, zileuton) with riluzole may increase the risk of riluzole-associated adverse reactions [see Clinical Pharmacology ( 12.3 )].
Source: FDA drug label (riluzole), Glenmark Pharmaceuticals Inc., USA, effective July 10, 2020 (SPL set f1ce57e8-d3fe-422c-8724-3101c258898a), via openFDA; the full label on DailyMed
What does the vemurafenib label say about riluzole?
Vemurafenib's label (effective August 28, 2026) does not name riluzole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (ZELBORAF), NDA202429 (Hoffmann La Roche), as published by Genentech, Inc., effective August 28, 2026 (SPL set 38eea320-7e0c-485a-bc30-98c3c45e2763), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Riluzole | Vemurafenib | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.293 per tablet 50 mg tablet | n/a |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once