What the FDA labels say about taking them together
Rifampin and trabectedin
Trabectedin's FDA label of June 29, 2026 names rifampin in its drug interactions section; the rifampin label PlainMeds reads does not name trabectedin. The trabectedin label: “Coadministration of YONDELIS with rifampin, a strong CYP3A inducer, decreased systemic exposure of trabectedin by 31%.”
Check it at the source: the rifampin FDA label on DailyMed (effective February 11, 2026, Lupin Pharmaceuticals, Inc.); the trabectedin FDA label on DailyMed (effective June 29, 2026, Apotex Corp.).
What does the rifampin label say about trabectedin?
Rifampin's label (effective February 11, 2026) does not name trabectedin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (rifampin), Lupin Pharmaceuticals, Inc., effective February 11, 2026 (SPL set b56004f0-f23d-47f6-80c7-39884fccbccc), via openFDA; the full label on DailyMed
What does the trabectedin label say about rifampin?
Trabectedin label, drug interactionsMechanism and Clinical Effect (s); Concomitant administration of trabectedin with rifampin, a strong CYP3A4 inducer, decreased systemic exposure of trabectedin by 31% [see Clinical Pharmacology ()].
Yondelis label (Janssen Products, LP, January 6, 2026), drug interactionsCoadministration of YONDELIS with rifampin, a strong CYP3A inducer, decreased systemic exposure of trabectedin by 31%.
Source: FDA drug label (Yondelis, NDA207953), Janssen Products, LP, effective January 6, 2026 (SPL set 472bd78e-be17-4b9d-90f4-9482c3aec9ff), via openFDA
Source: FDA drug label (EVDI), Apotex Corp., effective June 29, 2026 (SPL set c1d50f5c-4202-27f3-4798-a9708114ddea), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Rifampin | Trabectedin | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.679 per capsule 300 mg capsule | n/a |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once